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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPP2CA
All Species:
39.09
Human Site:
T227
Identified Species:
57.33
UniProt:
P67775
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P67775
NP_002706.1
309
35594
T227
F
G
Q
D
I
S
E
T
F
N
H
A
N
G
L
Chimpanzee
Pan troglodytes
XP_527011
309
35630
T227
F
G
Q
D
I
S
E
T
F
N
H
A
N
G
L
Rhesus Macaque
Macaca mulatta
XP_001084083
286
32771
R206
L
W
S
D
P
D
D
R
G
G
W
G
I
S
P
Dog
Lupus familis
XP_858531
311
35711
T229
F
G
Q
D
I
S
E
T
F
N
H
A
N
G
L
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
P63331
309
35590
T227
F
G
Q
D
I
S
E
T
F
N
H
A
N
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512852
302
34248
T220
F
G
Q
D
I
S
E
T
F
N
H
A
N
G
L
Chicken
Gallus gallus
P48463
309
35545
T227
F
G
Q
D
I
S
E
T
F
N
H
A
N
G
L
Frog
Xenopus laevis
Q6IP91
307
35104
Q224
F
G
S
D
V
V
A
Q
F
N
A
A
N
N
I
Zebra Danio
Brachydanio rerio
A8WGP3
311
35438
Q228
F
G
S
D
V
V
A
Q
F
N
A
A
N
D
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P23696
309
35450
T227
F
G
Q
D
I
S
E
T
F
N
N
T
N
G
L
Honey Bee
Apis mellifera
XP_623105
309
35425
T227
F
G
Q
D
I
S
E
T
F
N
H
S
N
G
L
Nematode Worm
Caenorhab. elegans
Q9XW79
333
37341
T250
F
G
A
D
A
S
K
T
F
C
E
T
N
G
V
Sea Urchin
Strong. purpuratus
XP_780423
308
35412
T226
F
G
Q
D
I
S
E
T
F
N
H
S
N
G
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q07100
313
35814
Q231
F
G
Q
D
I
S
E
Q
F
N
H
T
N
N
L
Baker's Yeast
Sacchar. cerevisiae
P23595
377
43028
Q295
F
G
Q
D
I
S
E
Q
F
N
H
T
N
D
L
Red Bread Mold
Neurospora crassa
P48580
327
37273
A245
F
G
Q
D
I
S
E
A
F
N
H
N
N
G
L
Conservation
Percent
Protein Identity:
100
99
89.9
96.7
N.A.
N.A.
99.6
N.A.
90.9
98
66
64.6
N.A.
93.8
96.1
59.1
93.5
Protein Similarity:
100
99
91.9
98.7
N.A.
N.A.
100
N.A.
93.1
99
81.5
81
N.A.
98.7
98
74.7
96.7
P-Site Identity:
100
100
6.6
100
N.A.
N.A.
100
N.A.
100
100
46.6
46.6
N.A.
86.6
93.3
53.3
93.3
P-Site Similarity:
100
100
13.3
100
N.A.
N.A.
100
N.A.
100
100
60
60
N.A.
93.3
100
66.6
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
78.5
62.6
81.3
Protein Similarity:
N.A.
N.A.
N.A.
87.2
71.8
86.8
P-Site Identity:
N.A.
N.A.
N.A.
80
80
86.6
P-Site Similarity:
N.A.
N.A.
N.A.
80
80
86.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
7
0
13
7
0
0
13
50
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
0
0
0
100
0
7
7
0
0
0
0
0
0
13
0
% D
% Glu:
0
0
0
0
0
0
75
0
0
0
7
0
0
0
0
% E
% Phe:
94
0
0
0
0
0
0
0
94
0
0
0
0
0
0
% F
% Gly:
0
94
0
0
0
0
0
0
7
7
0
7
0
69
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
69
0
0
0
0
% H
% Ile:
0
0
0
0
75
0
0
0
0
0
0
0
7
0
13
% I
% Lys:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% K
% Leu:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
75
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
88
7
7
94
13
0
% N
% Pro:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
7
% P
% Gln:
0
0
75
0
0
0
0
25
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% R
% Ser:
0
0
19
0
0
82
0
0
0
0
0
13
0
7
0
% S
% Thr:
0
0
0
0
0
0
0
63
0
0
0
25
0
0
0
% T
% Val:
0
0
0
0
13
13
0
0
0
0
0
0
0
0
7
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
7
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _